CoQ10 may be diminished by statins, will be diminished with age, much like melatonin, glutathione, other key life sustaining molecules.
Coenzyme Q10 (CoQ10) reviews are mixed, with some users reporting positive effects on fatigue, heart health, and migraine relief, while others report minimal or no noticeable benefits or even negative side effects. Some users on Drugs.com say they experienced positive effects on heart health and energy levels, while others on WebMD point out they experienced insomnia or other side effects.
Positive Experiences:
Some users on Walmart report that CoQ10 is great for heart health and helping with muscle cramps.
A meta-analysis found that CoQ10 supplementation can reduce fatigue scores.
Healthline reports that CoQ10 may effectively reduce the severity, duration, and frequency of migraine episodes.
Some studies suggest that CoQ10 can help improve exercise performance by reducing oxidative stress and improving mitochondrial function.
One user on Quora says they experienced reduced fatigue from Long Haul COVID symptoms after starting CoQ10.
One user on Quora says that CoQ10 helped regulate their irregular heartbeat.
Negative Experiences:
Insomnia:
A user on WebMD reported developing severe insomnia after taking CoQ10 for two weeks.
Side Effects:
Some users experience mild side effects like stomach upset, loss of appetite, nausea, vomiting, or diarrhea.
No noticeable benefit:
A video analysis suggests that 73% of people with mitochondrial issues may not experience any benefits from CoQ10 supplementation, and even when benefits are seen, they may be partial and difficult to distinguish from placebo effects.
Overall:
While CoQ10 is generally considered safe, individual responses vary. It's important to be aware of potential side effects and to consult with a healthcare professional before starting any new supplement, especially if you have pre-existing health conditions or are taking other medications.
MAYO CLINIC
By Mayo Clinic Staff
Overview
Coenzyme Q10 is an antioxidant the body naturally makes. Coenzyme Q10 also is called CoQ10. Antioxidants can help protect the body from cell damage. Cells use CoQ10 for growth and to make energy.
Levels of CoQ10 in your body lower as you get older. People with certain conditions such as heart disease or those who take medicines to lower cholesterol, called statins, may have lower CoQ10 levels.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.
Advertising & Sponsorship
PolicyOpportunitiesAd Choices
Meat, fish and nuts have CoQ10. The amount of CoQ10 found in these foods isn't usually enough to raise CoQ10 levels by much.
CoQ10 dietary supplements come as capsules, chewable tablets and liquid syrups. COQ10 also can be given by a tube inserted in a vein, called intravenous. IV is short for intravenous. CoQ10 might help prevent or treat certain heart conditions, as well as migraine headaches.
What the research says
Research on coenzyme Q10, also called CoQ10, use for specific conditions and activities shows:
Heart conditions. CoQ10 may improve congestive heart failure symptoms. Although findings are mixed, CoQ10 might help lower blood pressure. Some research also suggests that when taken with other nutrients, CoQ10 might help people recover from bypass and heart valve surgeries.
Diabetes. Some research suggests that CoQ10 may help lower cholesterol in people with diabetes. The effect could lower their heart disease risk.
Parkinson's disease. Taking even high doses of CoQ10 doesn't seem to help with Parkinson's disease symptoms.
Statin-induced myopathy. Some research suggests that CoQ10 might help ease the muscle weakness and pain that can happen when taking statins. There isn't enough evidence to know for sure.
Migraines. Some research suggests CoQ10 might lower how often migraines happen or how long they last. People who get migraines usually have to take the supplement for three months before they may see a benefit.
Physical performance. Because CoQ10 helps the body make energy, it's thought this supplement might improve how well the body performs during exercise. But research in this area has not been conclusive.
Metabolic dysfunction-associated steatotic liver disease, also called MASLD. A small research study found that people taking CoQ10 had reduced amounts of fat in their livers compared with people who didn't take CoQ10. More studies are needed.
Green light: Generally safe
Our take
Generally safe
Coenzyme Q10, also called CoQ10, supplements might be helpful for treating conditions such as congestive heart failure and preventing migraines. Most healthcare professionals think CoQ10 is safe, with few side effects. But ask your healthcare professional before you take the supplement.
Safety and side effects
Coenzyme Q10, also called, CoQ10 supplements seem to be safe. They cause few side effects when taken as directed.
Mild side effects might include stomach problems such as:
Upper stomach pain.
Loss of appetite.
Nausea.
Diarrhea.
Other possible side effects may include:
Dizziness.
Problems sleeping.
Tiredness.
Headaches.
Rash.
Irritability.
Healthcare professionals haven't decided if CoQ10 is safe to take during pregnancy or while breastfeeding. Don't use CoQ10 if you're pregnant or breastfeeding without your healthcare professional's approval.
Interactions
Possible interactions include:
Anticoagulants. Coenzyme Q10, also called CoQ10, might make the blood-thinning medicine warfarin (Jantoven) not work as well. This could raise the risk of a blood clot.
Top reviews from the United States
5.0 out of 5 stars Great stuff
Reviewed in the United States on June 26, 2025
Size: 60 Count (Pack of 1)Verified Purchase
Doctor has me on this everyday. I have a Motor Neuron Disease. This and B2 definitely help my energy levels.
5.0 out of 5 stars I can feel the improvement with this product
Reviewed in the United States on June 15, 2025
Size: 60 Count (Pack of 1)Verified Purchase
Been using CoQ10 for at least 15 years ever since I started on stations for cholesterol. Been on this particular brand for at least 8 years. Gone from 100mg to 200 mg just recently. Great product
One person found this helpful
5.0 out of 5 stars Would recommend
Reviewed in the United States on June 10, 2025
Size: 60 Count (Pack of 1)Verified Purchase
Really enjoyed this product. I will be 70 and two months, have no energy and when I started taking it. Two or three a day my energy started coming back and my blood pressure. My doctor said that a boy.
One person found this helpful
4.0 out of 5 stars It’s a matter of faith, I guess.
Reviewed in the United States on June 8, 2025
Size: 60 Count (Pack of 1)Verified Purchase
I buy it and I take it faithfully every night with my cholesterol meds. I have so much pain, how would I know if it does anything other than replace my body’s CoQ10? I don’t know. I trust this brand, but it’s more a matter of faith over Science.
One person found this helpful
5.0 out of 5 stars CQ 10
Reviewed in the United States on June 19, 2025
Size: 60 Count (Pack of 1)Verified Purchase
My second bottle! Love this stuff! Have more energy
5.0 out of 5 stars Helpful supplements.
Reviewed in the United States on June 5, 2025
Size: 60 Count (Pack of 1)Verified Purchase
These really help with muscle pain from withdrawal from certain medications. My doctor recommended Amazon for supplements. They do the job, and you can get them the next day.
5.0 out of 5 stars Necessary vitamins
Reviewed in the United States on June 14, 2025
Size: 60 Count (Pack of 1)Verified Purchase
A vitamin that is essential. Good price.
5.0 out of 5 stars Feel better take this product
Reviewed in the United States on June 8, 2025
Size: 60 Count (Pack of 1)Verified Purchase
Well packaged good product it does what it says