Hospice, search Dr. Atabekov in here, Dr Nathan Goodyear, Dr. Dino Prato, Brio Medical, Envita Medical, Dr. Andrew Jones, Dr. Tom Rogers.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10482585/
J Gynecol Oncol. 2023 Apr 24;34(5):e58. doi: 10.3802/jgo.2023.34.e58
Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer
Chi-Son Chang 1,*, Ji-Yoon Ryu 2,*, June-Kuk Choi 3, Young-Jae Cho 2, Jung-Joo Choi 2, Jae Ryoung Hwang 2, Ju-Yeon Choi 2, Joseph J Noh 1, Chan Mi Lee 4, Ji Eun Won 4, Hee Dong Han 5, Jeong-Won Lee 1,6,✉
Author information
Article notes
Copyright and License information
PMCID: PMC10482585 PMID: 37170725
Abstract
Objective
Fenbendazole (FZ) has potential anti-cancer effects, but its poor water solubility limits its use for cancer therapy. In this study, we investigated the anti-cancer effect of FZ with different drug delivery methods on epithelial ovarian cancer (EOC) in both in vitro and in vivo models.
Methods
EOC cell lines were treated with FZ and cell proliferation was assessed. The effect of FZ on tumor growth in cell line xenograft mouse model of EOC was examined according to the delivery route, including oral and intraperitoneal administration. To improve the systemic delivery of FZ by converting fat-soluble drugs to hydrophilic, we prepared FZ-encapsulated poly(D,L-lactide-co-glycolide) acid (PLGA) nanoparticles (FZ-PLGA-NPs). We investigated the preclinical efficacy of FZ-PLGA-NPs by analyzing cell proliferation, apoptosis, and in vivo models including cell lines and patient-derived xenograft (PDX) of EOC.
Results
FZ significantly decreased cell proliferation of both chemosensitive and chemoresistant EOC cells. However, in cell line xenograft mouse models, there was no effect of oral FZ treatment on tumor reduction. When administered intraperitoneally, FZ was not absorbed but aggregated in the intraperitoneal space. We synthesized FZ-PLGA-NPs to obtain water solubility and enhance drug absorption. FZ-PLGA-NPs significantly decreased cell proliferation in EOC cell lines. Intravenous injection of FZ-PLGA-NP in xenograft mouse models with HeyA8 and HeyA8-MDR significantly reduced tumor weight compared to the control group. FZ-PLGA-NPs showed anti-cancer effects in PDX model as well.
Conclusion
FZ-incorporated PLGA nanoparticles exerted significant anti-cancer effects in EOC cells and xenograft models including PDX. These results warrant further investigation in clinical trials.
Keywords: Fenbendazole, Epithelial Ovarian Cancer, PLGA Nanoparticle, Patient-Derived Xenograft, Drug Repurposing
⭐⭐⭐⭐⭐ Thank the stars above for Glasgow University's and City of Hope's recent proof of efficacy for fenbendazole, ivermectin, mebendazole.
https://www.gla.ac.uk/research/beacons/precisionmedicine/researchfeatures/cancerresearch/prostatecancerresearch/
Dr Helen Rippon, Chief Executive of Worldwide Cancer Research:
"This research could be a real game-changer for prostate cancer patients. Docetaxel is the main chemotherapy used to treat prostate cancer, but many patients end up developing resistance to the drug and their cancer comes back.
This bold new idea shows how we can use already existing medicines to bolster the effects of chemotherapy and hopefully improve outcomes for people with prostate cancer. We are excited to follow the progress of the research team as they take their work forward into clinical trials."
Dr Samuel Godfrey, Senior Research Information Manager at Cancer Research UK:
"Combining existing medicines with different cancer drugs is an exciting area of research, and this study shows some promising results which could lead to improved treatments for prostate cancer.
Out of the hundreds of medicines investigated, few would have suspected that an inexpensive worming treatment could so drastically increase cancer cell death in the lab. The next step will be to test this new drug combination in people with prostate cancer to see if it's safe and performs better than current treatments"
https://www.cityofhope.org/breakthroughs/drug-combo-shows-promise-against-triple-negative-breast-cancer
Novel drug combo shows promise against triple-negative breast cancer
By Letisia Marquez Mar. 02, 2021
Research
City of Hope scientists have combined a checkpoint inhibitor with an anti-parasitic drug, ivermectin, to successfully treat triple-negative breast cancer in preclinical research, according to a study published March 2 in npj Breast Cancer journal. (Ivermectin is also currently being used in clinical trials to treat and prevent COVID-19.)
Triple-negative breast cancer is a difficult type of cancer to treat because the tumor cells lack three key proteins — receptors for the hormones estrogen and progesterone and the protein HER2. Doctors now treat breast cancer based on targeting these three key proteins, but without them, triple-negative breast cancer has limited treatment options.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437363/
Korean J Physiol Pharmacol. 2022 Sep 1; 26(5): 377–387.
Published online 2022 Sep 1. doi: 10.4196/kjpp.2022.26.5.377
PMCID: PMC9437363
PMID: 36039738
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells
Deokbae Park,#1,# Jung-Hee Lee,#2,# and Sang-Pil Yooncorresponding author3,*
Author information Article notes Copyright and License information PMC Disclaimer
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Abstract
Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate the anti-cancer effects of benzimidazole on resistant cells, various cell death pathways were investigated in 5-fluorouracil-resistant colorectal cancer cells. The viability of wild-type and 5-fluorouracil-resistant SNU-C5 colorectal cancer cells was assayed, followed by Western blotting.
Flow cytometry assays for cell death and cell cycle was also performed to analyze the anti-cancer effects of benzimidazole. When compared with albendazole, fenbendazole showed higher susceptibility to 5-fluorouracil-resistant SNU-C5 cells and was used in subsequent experiments.
Flow cytometry revealed that fenbendazole significantly induces apoptosis as well as cell cycle arrest at G2/M phase on both cells. When compared with wild-type SNU-C5 cells, 5-fluorouracil-resistant SNU-C5 cells showed reduced autophagy, increased ferroptosis and ferroptosis-augmented apoptosis, and less activation of caspase-8 and p53.
These results suggest that fenbendazole may be a potential alternative treatment in 5-fluorouracil-resistant cancer cells, and the anticancer activity of fenbendazole does not require p53 in 5-fluorouracil-resistant SNU-C5 cells.
Keywords: Apoptosis, Colorectal cancer, Drug resistance, Fenbendazole, p53
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437363/
Korean J Physiol Pharmacol. 2022 Sep 1; 26(5): 377–387.
Published online 2022 Sep 1. doi: 10.4196/kjpp.2022.26.5.377
PMCID: PMC9437363
PMID: 36039738
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells
Deokbae Park,#1,# Jung-Hee Lee,#2,# and Sang-Pil Yooncorresponding author3,*
Author information Article notes Copyright and License information PMC Disclaimer
Go to:
Abstract
Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate the anti-cancer effects of benzimidazole on resistant cells, various cell death pathways were investigated in 5-fluorouracil-resistant colorectal cancer cells. The viability of wild-type and 5-fluorouracil-resistant SNU-C5 colorectal cancer cells was assayed, followed by Western blotting.
Flow cytometry assays for cell death and cell cycle was also performed to analyze the anti-cancer effects of benzimidazole. When compared with albendazole, fenbendazole showed higher susceptibility to 5-fluorouracil-resistant SNU-C5 cells and was used in subsequent experiments.
Flow cytometry revealed that fenbendazole significantly induces apoptosis as well as cell cycle arrest at G2/M phase on both cells. When compared with wild-type SNU-C5 cells, 5-fluorouracil-resistant SNU-C5 cells showed reduced autophagy, increased ferroptosis and ferroptosis-augmented apoptosis, and less activation of caspase-8 and p53.
These results suggest that fenbendazole may be a potential alternative treatment in 5-fluorouracil-resistant cancer cells, and the anticancer activity of fenbendazole does not require p53 in 5-fluorouracil-resistant SNU-C5 cells.
Keywords: Apoptosis, Colorectal cancer, Drug resistance, Fenbendazole, p53
https://healnavigator.com/fenbendazole-cancer-success-stories-and-testimonials/
Pat Humiston
August, 2023
I wish to share more good news. Since our texts, December 2022/January 2023, my husband has had two more PSA tests. Here is the recap of his tests . Lenny’s PSA continues to drop, as he continues to take the Panacur C daily.
Lanny – PSA Test Results
8.0 = Lanny’s PSA upon being diagnosed with prostate cancer, August 2021 Before Lanny ‘started’ radiation therapy, he had THREE WHOLE MONTHS of Panacur C daily. Lanny’s doctor said any PSA under 1.0 is considered CANCER-FREE.
0.8 = Lanny’s PSA after 3 months of Panacur C — BEFORE radiation therapy, October 2021 Lanny told his doctor about taking Panacur C, when the doctor told Lanny that his PSA was 0.8 (according to that very doctor, this PSA denotes cancer-free; however, this same doctor gaffed off the Panacur C and cancer-free PSA with NO explanation).
0.09 = Lanny’s 30-DAY POST RADIATION PSA TEST, WHICH DENOTES WAAAY CANCER-FREE, February 2022 Still no comment from any doctor . . . and I’m not anticipating one.
PSA Updates: 0.08 = February 2023
0.06 = June 2023
December 2022
Lanny was diagnosed with prostate cancer August 2021.
8.0 = Lanny’s PSA upon being diagnosed with prostate cancer.
Lanny’s doctor said any PSA under 1.0 is considered CANCER-FREE.
Before Lanny started radiation therapy, he had THREE MONTHS of Panacur C daily.
0.8 = Lanny’s PSA after 3 months of Panacur C — BEFORE radiation therapy.
Lanny told his doctor about taking Panacur C, when the doctor told Lanny that his PSA was 0.8 (which, according to that very doctor, this PSA denotes cancer-free; however, his doctor gaffed off the Panacur C and cancer-free PSA with NO explanation).
0.09 = Lanny’s 30-DAY POST RADIATION PSA TEST, WHICH DENOTES WAAAY CANCER-FREE.
Still no comment from any doctor and I’m not expecting any.
BTW, Lanny made a personal decision to continue using Panacur C as cancers are notorious for returning.
I started my husband on Fenbendazole about 4-5 months after diagnosis. We had already been using other supplemental alternatives, teas, etc. when I came across Joe’s story. I made sure he started after an MRI... Sure enough, his scans came back with remarkable improvement. His doctor knew we were using alternatives and said “what kind of black magic are you using”? Lol I told her, and she was impressed. He did 6 rounds of chemo initially but stopped due to liver and kidney damage with no change in lesions. He has continued fenben twice a day and his most recent scan he was NED! We are over the moon!
Laurice PanzellaLymphoma, March 2024
https://youtu.be/Qm06dgF3nNQ?si=zIwaJoa-PXfefxm5
I've been diagnosed with stage 4 peritonial cavity cancer, and i was advised by my doctor to take perembolizumab and Nivolumab wh immunoterapy drug which is very very expensive…
I've been diagnosed with stage 4 peritonial cavity cancer, and i was advised by my doctor to take perembolizumab and Nivolumab wh immunoterapy drug which is very very expensive
Just want to find out how effective is this drug considering the cost is there any one with this conditon pls advise
Im presently on ivemevtcin but can not get ferbendazole
I did joes protocal for stage 4b squamous cell carcinoma with other therapies. Still alive and well 4 1/2 years later when given 2 months in the begining
Tapas Mukhopadhyay, a lead cancer scientist at MD Anderson Cancer Center in Houston and an author of several medical publications on Fenbendazole/Mebendazole, actually thanked Joe Tippens by email for his efforts in bringing about awareness of the anti-cancer effects of the dog wormer Fenbendazole. The cancer scientist wasn't mad. He was happy with Joe Tippens efforts.
I just watched one YouTube video where Joe Tippens is speaking, and he said medical doctors from Vietnam were saying that a drug like Mebendazole/Fenbendazole, or maybe it was Mebendazole, was used to treat cancer in the 1960s in Vietnam. They knew it was effective in the 1960s. Had they shared that information in the 1960s with the whole world, my parents may not have died of cancer. The title of the video is, "Joe Tippens speaks at 2020 Annie Appleseed Project conference" on the Annie Appleseed Project channel. So, the information about worm medications being used to treat cancer has been known for 60 years.
my wife was cured after taking fenbendazol alone for 6 weeks 4 days a week.
My brother in-law had stage 3 pancreatic cancer. It was a good size tumor. In 8 weeks after starting Fenbendazole, NED!!
My cousins beating glioblastoma Grade 4 with fenben It is definitely the cure
I am being dismissed. Its worse when a female expresses concern. They label you depressed, anxious. These are nornal emotions. the fact that you are here, with really no gain to yourself,speaks volumes!! I am scared right now. Learning and diet change is keeping me going. I am trying the fenbendazole. I have to be here for my sons. I believe in these benefits. Mindset is the hardest, when you stand up for yourself and get shut down. You should see my medical records. I worked in the healthcare field. Ive seen so many people die, too early. keep teaching doc !! I'm listening.
Was diagnosed with breast cancer in 2020 refused to be bullied into doing the 'standard treatment. Until 2024 I research the various cancer protocol online whilst changing my lifestyle (clean eating + exercise by walking and various supplements). Came across Joe's cancer protocol and decided to undertake it and my tumor has shrunk to nil, they cannot locate it in my breast. They gave me 2-5 years if I did not have the surgery.
Do your due diligence and research, research the various alternative protocols to see if one is viable for your cancer condition.
In Joe Tippens' latest video, he states that in all 7 cases of pancreatic cancer it took 18 months for fenbendazole to put the cancer into remission. But it did.
https://www.youtube.com/watch?v=yn9PjK-kuuQ&t=16
My father 87, diagnosed with a glioblastoma brain tumor February 2024. Survival rate 5%. They could not operate. He could not tolerate chemo or radiation. He did a therapeutic ketogenic diet, fenbendazole, ivermectin, artemisinin. In Sept, the last scan oncologist told us the tumor is gone.
I surgically had a melanoma brain tumor removed at 73 yrs old. 1/5/2024. I had a really bad pet scan in May. I took 222 mg fenbendazole with my immunology drip each month. I was cancer free 12/20/2024. In May, my insides looked like a Christmas tree- I didn’t wait anymore. I started fenbendazole unbeknownst to my 5 doctors. In December I received NED- no evidence of disease. I read the report 3 times- I couldn’t believe it. Cancer free.
My Dad was diagnosed with prostate cancer 2 months ago. He cut all sugar from his diet and started taking Fenbendazole and alternating with Ivermectin. He just got his updated PSA results and it has dropped down 9 points so far. Hoping he continues and can completely get rid of it.
January 2024 I have been through glioblastoma brain tumour operation then radiation and chemo then 6 months of chemo (tablets), I have also taken Fenbendazole at 440mg with 6 days on and 1 day off for the last 4 months. Just had the MRI brain scan and the excellent news is just the minimal amount of scar tissue with shrinkage and no visible cancer.
I was diagnosed with a 1.5 inch colon cancer tumor in June 2024, started Fenbendazole and Artemisinin and declined the operation, December 5th my CEA tumor antigen test showed I am in normal ranges.
I have prostate cancer. Had the operation three years ago, the PSA went very low, but started to rise very very slowly. At a PSA of 0.14 I decided on 22 sessions of external beam radiation. Not knocked back PSA TO 0.072, STARTED TAKING FENBEN PRIOR TO TESTS, PSA IS NOW AT 0.041. my next PSA test is in a few days. I think PSA should be an acronym for, patient source of anxiety. However, I am a healthy 61-year-old and go hiking all the time. No side effects from the radiation or the operation really. Happy to live each day with hope and a smile on my face. I hope this drug is a cure for many cancers. thank you, dr for your time and kindness to humanity.
Diagnosed with PC after routine health checkup revealed PSA of 600 later to go as high as 2000, scans revealed metastasis, given 6 months, I am fully covered but turned down surgery, radiation and chemo. Started on Fenbendazole and RSO its been a long journey and feel like I came close to death twice, but now over two years and getting better everyday... 444 mg once a day…
Thanks for sharing.