Hypertension, there are two roads you can travel, but in the long there's still time to change the road you are on.
https://youtu.be/4NYVBtt0ioI?si=0Xygq9LxwQ6s_uHe
https://pmc.ncbi.nlm.nih.gov/articles/PMC10047379/
Curr Issues Mol Biol. 2023 Mar 8;45(3):2201–2212. doi: 10.3390/cimb45030142
Serratiopeptidase Attenuates Lipopolysaccharide-Induced Vascular Inflammation by Inhibiting the Expression of Monocyte Chemoattractant Protein-1
Vikas Yadav 1, Satyam Sharma 1, Ashutosh Kumar 2,3, Sanjiv Singh 1,*, V Ravichandiran 1
Editors: Chan-Yen Kuo, Guan-Ting Liu
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PMCID: PMC10047379 PMID: 36975512
Abstract
Lipopolysaccharide (LPS) has potent pro-inflammatory properties and acts on many cell types including vascular endothelial cells. The secretion of the cytokines MCP-1 (CCL2), interleukins, and the elevation of oxidative stress by LPS-activated vascular endothelial cells contribute substantially to the pathogenesis of vascular inflammation.
However, the mechanism involving LPS-induced MCP-1, interleukins, and oxidative stress together is not well demonstrated. Serratiopeptidase (SRP) has been widely used for its anti-inflammatory effects. In this research study, our intention is to establish a potential drug candidate for vascular inflammation in cardiovascular disorder conditions.
We used BALB/c mice because this is the most successful model of vascular inflammation, suggested and validated by previous research findings. Our present investigation examined the involvement of SRP in vascular inflammation caused by lipopolysaccharides (LPSs) in a BALB/c mice model.
We analyzed the inflammation and changes in the aorta by H&E staining. SOD, MDA, and GPx levels were determined as per the instructions of the kit protocols. ELISA was used to measure the levels of interleukins, whereas immunohistochemistry was carried out for the evaluation of MCP-1 expression. SRP treatment significantly suppressed vascular inflammation in BALB/c mice.
Mechanistic studies demonstrated that SRP significantly inhibited the LPS-induced production of proinflammatory cytokines such as IL-2, IL-1, IL-6, and TNF-α in aortic tissue. Furthermore, it also inhibited LPS-induced oxidative stress in the aortas of mice, whereas the expression and activity of monocyte chemoattractant protein-1 (MCP-1) decreased after SRP treatment. In conclusion, SRP has the ability to reduce LPS-induced vascular inflammation and damage by modulating MCP-1.
Keywords: serratiopeptidase, vascular inflammation, lipopolysaccharides, monocyte chemoattractant protein-1, oxidative stress, vascular smooth muscle cells
I have several issues that I feel will help.. Hopefully my ongoing stomach issues that honestly i feel are caused by female related scar tissue. But I know someone who cured his severe chrohns disease with serapeptase.
I used fairly high doses of Serrapeptase and Nattokinase to remove scar tissue in my retinas that was caused by breakage of the tiny capillaries from abnormally large, deformed white blood cells caused by leukemia. The retina specialist who diagnosed the illness knew studies on the enzymes. He said after a year that there was absolutely no sign I had ever had scarred retinas.
So my wife took her first dose of serrapeptase as directed this morning. She has back and neck pain that is causing her arm and wrists to go numb. Within an hour out of nowhere she was raving about the relief she was getting. I was skeptical but it appears that it works!!
I have always had seasonal allergies which make it difficult to breathe through my nose. I started the Serrapeptase over a month ago and I have to say that I can now breathe just fine. Very little congestion. I can’t say for sure that it has helped but it’s the only thing I have done differently. Now I’m hoping it will help cellulite! I know that’s a stretch but I can hope!
63 year old female. I started 1 week ago,, suffered extreme IBS after surgery.. I started taking 30mg Pain has decreased tremendously. Scar tissue from surgeries are beginning to relax for the 1st time in 10 years. I breathe much easier. Wow amazing…
I had a fibroid years ago and took Vitalzyme systemic enzymes and it shrunk the fibroid. When all else fails, systemic enzymes is always my go too
Hi Stephen Cabral. So, serrapeptase actually gets into the blood and can dissolve proteins? If Serrapeptase were to dissolve a large plaque (say an old stabilized plaque for example) from the artery would this be safe? Sudden plaques bursting leads to thrombosis, but does serrapeptase slowly dissolve old plaques without leading to fatal thrombosis? What has the research found? Does Serrapeptase increase cardiac events in people with a history of CVD and heart issues such as these? Important questions to ask, as the #1 killer is CVD.
First came across serrapeptase when my eye doctor in India prescribed it for a week post cataract op to help break down any residues from the old cataract ..i researched it and found out so many other benefits. i took it when i had covid to help with mucus in the lungs it works and no side effects 😊
I didn't hear you mention DVTs, Scar Tissue in the lungs or clearing the Lymphatic System congestion (Lymphedema ) and Edema . I understand that Proteolytic enzymes like Serrapeptase, Lumbrokinase and Nattokinase are all Super enzymes for these conditions. Would you please make a video about each one of these conditions and Proteolytic enzymes. would you please touch on the subject of dosages of each of the Proteolytic enzymes.....What are the differences of each and is one better than another for certain conditions? Thank you so much !
Have just started using, hopefully to eat up some cysts in my liver. I’m T2d and always dealing with hyperglycaemia, however I’ve just realised why my blood sugars have settled low! Amazing. I’ll take it forever now.
I've been taking Serrapeptase for about a decade now and no problems with the maximum dose 240,000 units. I was originally taking 5 to 6 Aleve in the morning to be vertical. Bad knees!!
I was watching a video one morning while having my cup of Joe and DC was talking about joint pain; knees in particular. He wrote the word on a chalkboard and I wrote it down. About 5 weeks of research I started using it. About three years ago I underwent my first knee replacement surgery and just before I was taken in for the surgery the anthesiologist asked if I was still taking Serrapeptase. My reply was yes. And he told me he had never heard of it had to look it up. And in the same breath stated " THAT STUFF IS AMAZING "
I responded I know!
Steve Winning | Age: 65-74 | On supplement for 10 years or more |
1/28/2023
Condition: Other
Overall rating 5.0
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I first took Serrapeptase about 12 years ago for a very painful hip which required replacement and was taking loads of painkillers which I didn’t like to do. Serrapeptase was recommended to me by a naturopath friend and within a few weeks of starting on it I stopped painkillers altogether. I found also that my back pains disappeared, my general arthritic pains greatly reduced, my sinuses were much clearer, my breathing improved, scars are much less visible and generally I felt lighter and healthier and younger!! I have continued taking it every day, so over 12 years now, I take one 40,000iu capsule first thing in the morning (I don’t eat breakfast) and I can honestly say it has absolutely changed my life for the better.
I have recommended it to hundreds of people (Im a private hire driver) and only 2 people have said they felt no difference and none have reported any bad effects. It has to be taken on an empty stomach or it will be destroyed by the digestive system. One of the claims of it is that it digests/dissolves potential blockages in your blood, I certainly haven’t had any problems with blood pressure or blockages and I’m happy thinking that the Serrapeptase is working away quietly keeping things clear. I’ve always bought online from GoodHealthNaturally and I’ve found them to be very consistent and reliable and fast delivery.
Jamie | Age: 45-54 | On supplement for less than 1 month |
2/11/2023
Condition: Sinusitis
Overall rating 5.0
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My wife found this stuff at Dad’s Organics and I was really skeptical because I’ve never heard of this stuff and I’ve researched a lot. I had a bad root canal (upper molar). The infection was getting into my sinuses and eventually into my ear. Many dentist visits and many more doctors appointments and antibiotics were always the prescription. My ear and sinuses hurt all the time and it eventually got so bad my doctor thought I had shingles coming out under my nose and under my left eye. It hurt so much that I was having really bad thoughts and my mental health was in a really bad place. This stuff was a miracle for me. Took about a month at a higher dose but I finally feel fantastic again. My ear doesn’t hurt, the pain is gone from my face and I’m breathing normally through my nose again. I love my life again.
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I started taking Serrapeptase about 10 months ago as it is supposed to reduce inflammation and help clean and renew damaged arteries. The result has been that my blood pressure has been reduced from 155/98 to 98/68 which is telling me that my arteries are starting to be flexible again.
Ricky |
1/26/2023
Condition: Other
Overall rating 5.0
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I had low grade fever for four years and no one knew what was wrong with me. I started serrapeptase and it’s now my 6th month, my fever went down after two days of taking. I had covid too but recovered with not much symptoms, and negative after three days only. I am now hoping my Tarlov’s cyst in my sacrum will reduce its size… I take 360,000 twice a day
TrueBeliever | Age: 55-64 | On supplement for 1 to 6 months |
8/2/2022
Condition: Other
Overall rating 5.0
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After reading studies on both Serrapeptase and Nattokinase, I started using them both, Natto for the first week, then both, twice a day, four capsules in all, daily. My interest was in cleansing my circulatory system of any atherosclerosis build-up. Now after 1 month, my circulation (significant improvement), sleep (not interrupted by circulation issues), heart beat (rare to no skips), appetite (much less), stools (firmer), nocturia (gone) are all positively impacted.
My research indicates that tumor fibrin encasement is dissolved, permitting tumor necrosis factor to prevail.
So if any exist, they are more effectively destroyed. It took about 3 weeks for my body to settle in to this new reality. I'm hoping to lose 30 lbs with reduced appetite assistance of these enzymes. Extremely minor head-ache when I first took serrapeptase. Plus I can sense the enzymes at work in my mouth. I may report back when I ready my weight loss goal :-)Read Less
Condition: Other
Overall rating 5.0
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I was not able to turn over in bed because of severe pain and if I got down on the floor, I had to painfully crawl to furniture to drag myself up. That was over 16 years ago. I have taken it since. I like the Doctor's Best formula from Vitacost.com. I am79 years old. I have a coil in my brain because of an aneurysm over 20 years ago. Every year I have an MRI that covers my neck and brain. The first year the doctor commented that I had some beginning plaque in my carotid arteries. I started the serrapeptase a few years later. The literature says ir can take up to a month to be effective. I awoke on the 4th morning with no pain. I am on coumadin and have no difficulty adjusting my diet to maintain the correct blood levels.
First of all, serrapeptase is a proteolytic enzyme that reacts on proteins, hence the Empty stomach rule. Take with a Full glass of water is to prevent stomach pain. If you have pain, drink more water an it will go away immediately. Wait an hour to eat or drink Anything but water! My latest MRI shows complete clear arteries in my brain and neck. My 16 year old cat cried if we stroked her and could not climb on our low sofa without clawing her way up in great pain. I gave her SerraPet and dripped water in her mouth with a straw. Over night she was zooming around like a kitten , moving for the sheer joy of it. I would ask if she wanted her pill and she came running. She would paw the pil container and meow at me if I forgot. Hw she made the connection between the pill and no pain, I will never know. Her last year was a joyful one without pain. I use serrapeptase topically also for black bruises and varicose veins. Just open a capsule and make a paste with water. You can literally watch a black bruise fade away in 6-8 hours. The varicose vein took a couple of weeks.
DebW | Age: 65-74 | On supplement for 1 to 6 months |
7/24/2022
Condition: Other
Overall rating 5.0
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I started this enzyme as a means to help with RA and inflammation. Imagine my shock when 2 weeks later I no longer have nerve pain or neuropathy in my legs and am off gabapentin entirely. If I knew this helped I would've taken it years ago. It can't be anything else unless someone can explain it otherwise.
Shauna | Age: 55-64 | On supplement for 2 to less than 5 years |
7/20/2022
Condition: Sinusitis
Overall rating 5.0
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Actually, I have fibromyalgia. I was desperate. I found info on Serrapeptase on the internet. I started taking 120,000 SPUs in the morning and in the evening on an empty stomach. Was completely pain free in about 2 weeks. It was a miracle to me. I continue to be pain free 4 years later. My husband takes it occasionally for various aches and pains. Sometimes I up the dose, other times take less. I recommend it to anyone in pain.
Dr.Rasheed | Age: 55-64 | On supplement for 10 years or more |
7/11/2022
Condition: Other
Overall rating 5.0
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Despite many scientists constantly saying Serratiopeptidase has no scientific support,as I am a physician, I have seen benefits with Serratiopeptidase as an anti-inflammatory medicine for many different conditions. If personally speaking, I am an angioplasty and stent inserted 57 years old person in 2009. Since then I have not taken any other medicines or supplements,. but still consuming Serratiopeptidase 10mg and Vitamin C 1g three times daily.
Regular moderate exercise continuing. Avoiding sugars and carbohydrates as much as possible in the diet. Various vegetables 60%, meat (mainly beef) 20-25%, homemade coconut oil + tallow butter 05-10%, different kinds of sprouted beans (cooked) 05-10% and enough fluids (water, tea...),.This is my regular diet. Fish and eggs are often used instead of meat. I am 57 years old and have no health problems (not even in my personal life). All these are concludes anti inflammatory effect of Serratiopeptidase.
LadyFlameE | Age: 55-64 | On supplement for 2 to less than 5 years |
6/6/2022
Condition: Other
Overall rating 5.0
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Anyone saying this does not work is feeding misinformation, this along with NATTOKINASE is what is needed for recovering from spike proteins. It clears scar tissue breaks up clots removes mucas acts like a NSAID with no side effects, the list goes on and on. It has been used in Asia and germany for many years to help with blocked arteries and female fallopian tube issues as well as fibroids the list goes on and on.
The idea is to get the serrapeptase THROUGH the stomach where it can digest in the intestines. Serretia, from Arthur Andrew Medical, states in the directions to take with 8 ounces of water on an empty stomach, which would seem to dilute the stomach acids long enough for the pill to pass through. The pill has a coating called "Acid Armor" that I suppose is their version of an enteric coating.
I've never experienced any problems with burping or gastric problems. However, my wife took it and for the first few times, she didn't use 8 ounces of water but just enough to get the pill down. (She didn't read the directions). She asked me why I never started burping when she did every time. Once she started drinking the 8 ounces of water, she no longer had the problem.
As far as "If it works" goes, I started taking it to see if it could help with my arteries to help bring my blood pressure down over time. About 4 hours after I took the first dose, I got up out of my chair and realized that my hip (that has been hurting for around 8 months) was not hurting at all. That wasn't even what I started taking it for. Since then, an old shoulder injury that has been basically an ongoing, occasional pain, also stopped hurting altogether.
My wife, after seeing how it worked with me, started taking it to see if it would help with her foot pain (She's a surgical nurse, 4 foot 10 and she's chasing 6 foot 2" doctors around for 90 to 100 or so patients a day.) It seems to be really helping her feet and her lower back pain has gone away, also.
It's been 5 years since this video was posted so you probably already know all this by now. I just thought I'd put in my 2-cents. Thanks for posting!
I was a 35 year heavy smoker, and have been told by 3 doctors that I have lots of scar tissue in my lungs. Nothing I did worked. I tried deep breathing and other things and I can say that in my experience after being on Serrapeptase for 4 weeks I'm definitely seeing a marked improvement in my breathing. I can breathe more deeply and fully and I haven't heard a "lung crackle" in over a week which used to be a daily occurrence. I can't say it works for everyone but it has definitely made a difference in my life. I take it at 5am with 7 oz of water and go back to sleep. A couple of hours later I wake up and eat breakfast.
I want to share something that happened to me just recently. I have had arthritis for most of my life and desperately been trying to find something natural to help with the discomfort. Well, Ive been reading about Serrapeptase for awhile and decided to give it a shot. I have been taking it for about 2 weeks now and I haven't felt this good in years! Not only has my joint pain been diminished but something totally unexpected and miraculous also happened. I've had a bad cough for over two years now. It kept me from sleeping at night and I couldn't get rid of it. I was actually afraid to have it checked because I thought it was something very serious. I just didn't want to know. I am absolutely shocked that my cough has gone away after taking Serrapeptase! I always had congestion and phlem and a cough but that is now all gone! I wasn't even expecting that to happen in the least. I am so damn happy I tried this people. I'm not qualified to recommend anything to anyone but this has been nothing short of miraculous for me. I am feeling so much better these days and it has improved my attitude so much also. That's my story. Good health to all of you.
Mr. & Mrs. Covarrubias 5.0 out of 5 stars Important that everyone knows before buying!!
Reviewed in the United States on April 3, 2019
Update: ok so i wrote this originally on April 3rd of 2019.
Updating today on May 21st 2020
I found out I suffer from a slight iron deficiency. I'm not sure if that played a role in serrapeptase causing so much distress...
But it seems like it would.
I've taken breaks from it for weeks and even months but the reaction is still the same.
Liquid stool, fever, body aches, chills and horrendous straining vommiting as well as lips turning blue and tiny red dot pin pricks on my face from all of the straining.
You are not supposed to take this with any blood thinners serrapeptase thins your blood on its own..
Adding low iron anemia to it may have played a role in why i had such a terrible reaction.
I also took a lot of collagen for about a month and a half.. Tried it again.. The symptoms happened again... Only a little less harsh. So who knows.. Maybe if i built up my collagen for 6 months to a year i might be ok..
All i know is i believe in this bc i actually passed a fibrous dark colored tissue after o ly 3 weeks. It was NOT a period clot. Way too firm and almost a black color.
After the first day i felt my ovaries "wake up" with tingling and almost a menthalated feeling.. It was unreal
Thats why i still believe in it. I felt like i was going to die but i passed what i believe to be a fibroid. Thats a tangible result!!
Just be careful. It hit me out of the blue after 3 weeks of taking 0ne million units.. Feeling great...Then BAM! doubled over in pain and losing control of my bowls while not being able to catch my breath.
Oh.. And i took FOUR different brands and had the exact same result.
3 different smaller and smaller doses..
I even broke one open and used 1/8 of the smallest capsule.. (As directed by a so called serrapeptase expert) Still reacted badly..
And yes... They were all enterically coated
It made ZERO difference.
And i was told to taking digestive enzymes.. Did that for three months.... Tried serrapeptase again.. ZERO effect.. I still endured the worst gut pain, and liquid stool but no fever and chills that time
I wish i could handle it bc i know it works 👍
Good luck out there
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Ok. So let me first start by saying i too became VIOLENTLY ILL one day out of the blue. I did just fine with it for like a month and one day i ate some pretty bland food and puked strenuously 6 different times. I had liquid bowel movements as well. The whole thing was terrifying. It lasted about 10 -12 hrs .. Just feeling drained and miserable. BUT!
I now know WHY everyone is getting sick and its not a defect of the brand it is a defect of the user.
Serapeptase breaks down proteins. Ur gut has a protective lining in it called biofilm.
Biofilm is made up of proteins.
So what did we stupidly do?
Thats right. We slowly stripped it away until we had none (or a small amount) causing the violent and terrible reaction that it causes.
Whats the solution? Depends on the person.
Take a couple of weeks to build that film back and then SCALE BACK ur doses significantly. Start with one 40,000 unit pill PER DAY and dont go overboard.
Why did i give this a 5 star rating? Bc while i was wretching and going to toilet i passed an endometrial polyp!
Its doing its job!!! Complete breakdown of a polyp in only 3 weeks??? I also felt my formerly dormant/ blocked fallopian tube twinge and wake up after 10 years of silence. A nasty scar from childhood is fading after 20 years.
Im taking a small break and getting right back to it. I love this stuff.
We all just have to be smarter about how we take it. Do more research before blaming the product. Good luck everyone out there!
882 people found this helpful
Kaitlyn 5.0 out of 5 stars It cleared my fallopian tubes!!
Reviewed in the United States on January 1, 2019
This stuff is amazing!!!! I tried for 2 years to get pregnant and couldn't. I was pregnant once in that time frame but the baby was ectopic. I found out after that that I had endometriosis and there was no cure only "temporary treatments". I heard about Serrapeptase and bought it right away along with 2 Chinese herbal teas, also bought from Amazon, and within a month and a half I was pregnant!! I am now 31 weeks pregnant with a healthy baby girl! Please give this a try if you are in a similar situation!!
396 people found this helpful
Louiza Thomas 5.0 out of 5 stars OMG I AM PREGNANT!!! Reviewed in the United States on June 16, 2018
This is a miracle! I took this item just for 2 months and now I'm pregnant! I have been trying(6months) for a baby after my myomectomy, and finally we are PREGNANT!!!
How I took it:
I actually took this with Xi Xian Coa and Yi Mu Coa, right after my period and a day b4 ovulation. It's a short window but worked!
Experience after taking it:
I was urinating frequently and I assumed it was flushing me out; but the 3rd month I decided not to take it and we baby danced. Surprisingly I got a positive pregnancy test(for the first time in my life)!
I will be posting a video on my Youtube channel(Beautiful Chocolate) soon and answering any questions. So feel free to check me out.
I hope this was helpful to anyone trying to conceive! Baby Dust on You!!!
Amazon Customer 5.0 out of 5 stars It Works!!
Reviewed in the United States on May 6, 2017
I used both teas, Serrapeptase, castor oil packs, and fertility massage. I was diagnosed with blocked tubes in 2011. I'm now 5 weeks pregnant. I recommend these for any woman with blocked tubes or PCOS.
Hiddentalent_21 5.0 out of 5 stars They work! Reviewed in the United States on February 26, 2018
What I like most is that they work and do its job. The doctor said my tubes were blocked and the only way to conceive was though IVF. After 3 attempts with it I toke a break and started taken Serrapeptase supplements along with Folic acid, magnesium,B6,B12,cod Liver oil, Bee pollen, wheat Grass, and a militvitiman and Ubiqunol. I also made a green smoothie everyday and also ate avocados,eggs, sweet potatoes, Spanich,Kale and Berries. I also exercised daily. I did mostly Cardio and drink plenty of water. Lastly make sure you take these on a completely empty stomach or you will get super sick. I promise you they will work for you. I toke them for about 3 weeks with all the other stuff and finally was able to conceive naturally!
Top reviews from other countries
Jesikah Logan 5.0 out of 5 stars Unblocked my sinuses, varicose veins slowly "disappearing"
Reviewed in Australia on May 23, 2020 29 y.o. female, Australia
Sinuses started to unblock within 3 days of starting this product. Have been taking for about three weeks now and have noticed a significant fading in stretch marks and varicose veins. I'm a med student, science enthusiast and the world's greatest supplement cynic . . . and I'm a newly converted believer. I can breath through my left nostril for the first time in 10 years (no more mouth breathing), have tried multiple Western-medical treatments in this time to no effect.
Have had a couple of days were my guts felt a bit funny a few hours after ingesting, had a break the next day and started again on course day after that (1 capsule a day) each time this occurred. Would recommend dosing with common sense, given its reputation for adverse GIT effects in new consumers. Also get a warm, dry feeling in my eyes sometimes, but that could be the cold weather this time of the year, not entirely sure.
Overall, I would highly recommend this product for sinus issues and scar tissue repair.
Flora Yee 4.0 out of 5 stars Good product Reviewed in Singapore on February 6, 2021
Verified Purchase
Helps control blood clots when you have fibroids ..
but it’s considered like a blood thinner, so need to exercise caution when taking this
James
4.0 out of 5 stars Works! Reviewed in Australia on December 28, 2019
Verified Purchase
It is good stuff. Notice sinus health improvement very quickly.