The effect of vitamin C in sepsis and ards.
https://wholefoodsmagazine.com/columns/vitamin-connection/are-liposome-encapsulated-vitamin-c-and-or-the-levy-multi-c-protocol-more-effective-than-intravenous-vitamin-c/
Any delivery system that can achieve delivery of its payload (in this case vitamin C) into the cytoplasm, or even more deeply into the mitochondria, endosomes, or nuclei, is nearly always the most desirable way to put that payload into the body, especially without the consumption of energy, or with the relatively minimal consumption of energy.
The fusion process of liposome-encapsulated delivery of vitamin C into a cell interior via pinocytosis. This is an energy independent process and is very efficient. (Courtesy of Riteksha Patel, Slideshare.net.)
Passwater: This is extremely important. The objective is not just to increase the level of vitamin C in the blood, but to get as much vitamin C into the cell interior and the organelles within the cell interior as possible.
Levy: It is of interest to know that liposomes imitate the way in which cells throughout the body communicate and transfer various substances. This is achieved via a class of agents known as extracellular vesicles, also known as membrane vesicles. Classified largely by size, these vesicles consist of microvesicles, exosomes, apoptotic bodes, argosomes, and liposomes. They all have the lipid bilayer membrane structure, allowing the transfer of contents, including RNA, immune factors, and even factors involved in stem cell function, between and among the cells of the body.
https://wholefoodsmagazine.com/columns/vitamin-connection/are-liposome-encapsulated-vitamin-c-and-or-the-levy-multi-c-protocol-more-effective-than-intravenous-vitamin-c/
As it turns out, high endogenous cortisol levels are present in septic patients near-death, as the body-wide oxidation of intracellular hydrocortisone receptors seen in advanced sepsis causes a state of cortisol resistance, resulting in an attempted compensation by the body to produce more cortisol in a futile attempt to result in active, cortisol-bound receptors having their normal physiological impact in the nuclei of the cells throughout the body.
What appears to happen, then, is that the initial dose of vitamin C reduces the oxidized receptors, and the cortisol effect then kicks in as the receptors again become functional. Furthermore, the cortisol itself facilitates the intracellular uptake of vitamin C via increased expression of SVCT2 vitamin C transporters, making vitamin C and hydrocortisone very synergistic in their clinical impact.
It appears that vitamin C and hydrocortisone are the two most important and powerful naturally-occurring anti-inflammatory agents.
Paul
5.0 out of 5 starsVerified Purchase
The importance of liposomal vitamin C
Reviewed in the United States on September 6, 2020
I'm glad the price on these went down from $35 a bottle to $18. Talk about price gouging.
Nobody in the media seems to be talking about ways to help boost our immune system to help protect our bodies from contracting Covid-19.
Personally, I had many of the Covid-19 symptoms and started this regimen. Not all of these things came in at the same time from Amazon. The last thing to come in was Quercetin. Once I started taking it in combination with the other vitamins, I felt much better within 24 hours and completely back to normal within 48 hours.
A friend of mine tested positive for Covid-19 and his father had the same symptoms but wasn't tested. I brought him this regimen the same day of the positive test result. Within 24 hours both were feeling much better and within 48 hours they were completely symptom free.
I found this regimen shortly after developing some of the symptoms. This video can be found on YouTube and it is called "Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)."
In the video, Dr Seheult (who works directly with Covid-19 patients) recommends the following regimen using these over-the-counter vitamins and supplements. DISCLAIMER: always consult your physician before adding any new supplements to your diet.
1) Vitamin C (2:14)
2) Vitamin D (4:21)
3) Quercetin (7:02)
4) NAC (8:17)
5) Zinc (9:47)
1) Liposomal Vitamin C - is an anti-inflammatory and antiviral. Specifically liposomal vitamin C has a much higher absorption rate than regular vitamin C. The only thing better is intravenous vitamin C.
2) Vitamin D - even if you can get 15 minutes of sun every day, you should still consider adding a vitamin D supplement to your diet. Multiple studies have proven the effectiveness of vitamin D towards fighting Covid-19. If you do a Google search for "Vitamin D mortality rates Covid-19," you will find all kinds of scientific research.
In one of the studies from Indonesia, patients with normal levels of vitamin D, the death rate was 4%. In patients with insufficient levels of vitamin D, the death rate was 88%. In patients with deficient levels of vitamin D, death rate was 99%.
3) Quercetin - has the ability to interfere with the enzyme in your cells that the coronavirus requires to get in your cells and begin replicating. Similar to Hydroxychloroquine, Quercetin is a zinc ionophore. A zinc ionophore activates the port to allow zinc to enter a cell. Once in the cell, zinc is then able to block the enzyme RNA-dependent RNA polymerase, which turns off viral replication.
4) NAC also called N-Acetyl Cysteine - people claim it helps shorten cold, flu, & sinus infections. It is used to increase levels of glutathione, which is one of the body's most important antioxidants. It also helps burn fat more effectively through its ability to improve insulin sensitivity, which means it helps the body use insulin more efficiently to help treat Type 2 diabetes. NAC's ability to replenish & regulate glutamate levels helps improve brain health for conditions like Alzheimer's, depression, anxiety, bipolar disorder, schizophrenia, obsessive-compulsive disorders (OCD), and other addictive behaviors. Warning, if you have asthma or bleeding problems, consult your doctor who may tell you to avoid NAC.
5) Zinc - it is well known that zinc (Zn) possesses a variety of direct and indirect antiviral properties, but over time it decreases copper levels in your body. Administration of a zinc supplement enhances antiviral immunity to restore depleted immune cell function.
Zinc also protects or stabilizes the cell membrane which contributes to blocking of the virus entry into the cell and inhibits viral replication. Zinc does this by blocking RNA-dependent RNA polymerase (RdRp), the core enzyme of their multiprotein replication and transcription complex that is critical for the copying of viral RNA.
Fortunately, there are molecules that can act as facilitators and enhance the entry of zinc into the cell. These are known as zinc ionophores. In addition to Hydroxychloroquine, other things like Quercetin and to a lesser extent Green Tea are zinc ionophores (both of which can be bought over the counter).
How zinc ionophores work. Zinc ions stay outside the cell. The cell’s membrane and binding molecules limit the ability of zinc to penetrate into the cell. A zinc ionophore activates the port to allow zinc to enter a cell. Once in the cell, zinc is then able to block the enzyme RNA-dependent RNA polymerase, which turns off viral replication.
6) Alkaline Water - this was not mentioned in the above video, but has been mentioned in other videos. It is used to raise your alkaline levels and it is also an anti-inflammatory.
“We made a comparative study with a batch of 50 patients, who were given 500 mg of regular Vitamin C twice every day, while another 50 (treatment batch) were given high dose (4 g palatable liposomal Vitamin C) a day,” he said.
The medical records of the patients were analysed, and the epidemiological, clinical, laboratory, treatment and outcome data was collected and reviewed by internal medicine specialists. All patients were tested for Covid-19 from a naso-pharyngeal swab by real-time reverse transcription polymerase chain reaction (RT-PCR).
The patients were subjected to nasal swab and repeat RT-PCR on the 10th, 11th and 14th day of admission.
Patients treated with high dose oral Vitamin C (in drink form) had an increased test rate of RT-PCR negative. “This gave us a ray of hope. The expected rate of clearance is 14 days, but the treatment batch showed clearance even on the 10th day,” said Manickam, who incidentally was the brain behind the formulation.