There are various forms of Berberine that have better absorption and bioavailability, and there is Liposomal Berberine in the marketplace.

https://www.mcgill.ca/oss/article/medical-critical-thinking/berberine-dont-swallow-hype-or-pill

Perhaps the most interesting laboratory finding, given the rising global tide of type 2 diabetes, is the control that berberine may exert over blood sugar. But there is a problem. Berberine is virtually insoluble in water and has low intestinal absorption which means it has poor bioavailability. That is why current research focuses on improved delivery systems. These include nanoparticle formulations that encapsulate berberine to improve bioavailability and synthetic modifications of the molecule to increase solubility. Because of berberine’s poor bioavailability, supplements on the market are likely to be useless. However, some derivative of berberine, may yet make it to the physician’s prescription pad. But it won’t be for weight loss. And don’t hold your breath.