VDR polymorphisms and Type I Diabetes, no mention of Liposomal D3/K2 in their research and I'll show you why there should be.
Medicine (Baltimore). 2021 Jul 16;100(28):e26637. doi: 10.1097/MD.0000000000026637
Association of vitamin D receptor gene polymorphism with type 1 diabetes mellitus risk in children
A protocol for systematic review and meta-analysis
Yalin Ran a, Suyuan Hu a, Xiaohua Yu b, Renjun Li b,∗
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PMCID: PMC8284714 PMID: 34260558
Abstract
Background:
Recent genetic association studies showed that there are contradictory results on the relationship between vitamin D receptor (VDR) gene polymorphisms and type 1 diabetes mellitus (T1DM) risk in children. The purpose of this systematic review is to collect the currently available evidence to evaluate the relationship between VDR gene polymorphisms and the risk of T1DM in children.
Methods:
Such medical databases as Wanfang Data, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Chongqing VIP Chinese Science and Technology Periodical Database, PubMed, Embase, and Web of Science were extensively searched for relevant literatures published before June 2021 with the focus on the relationship between VDR gene polymorphisms and the risk of T1DM in children. The risk of bias was evaluated as per the Newcastle-Ottawa Scale by 2 independent researchers. Meta-analysis was performed to quantify the relationship between VDR gene polymorphisms and T1DM risk in children.
Results:
The results of this meta-analysis would be submitted to a peer-reviewed journal for publication.
Conclusion:
The relationship between VDR gene polymorphisms and T1DM risk in children is explored via this meta-analysis.
https://www.hindawi.com/journals/bmri/2019/8326246/
Volume 2019 |Article ID 8326246 | https://doi.org/10.1155/2019/8326246
Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development
Maryam Mukhtar ,1 Nadeem Sheikh ,1 Saira Kainat Suqaina,1 Andleeb Batool,2 Naz Fatima ,1 Rabia Mehmood,1 and Sabeen Nazir1
Academic Editor: Dimitrios P. Bogdanos
Vitamin D is an anti-inflammatory molecule and has a role in prevention of arthritis development. Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. VDR gene polymorphism leads to dysfunctioning of 1, 25(OH)2D3 ultimately disease onset.
The purpose of current study was to evaluate the effect of vitamin D level and VDR gene polymorphism on rheumatoid arthritis and osteoarthritis. Blood samples were collected from case and control after taking written consent.
Serum was separated and vitamin D level as determined from each sample by ELISA. DNA was extracted from each blood sample and amplified by using gene specific primers. Genotyping was performed by Sangers sequencing and PCR-RFLP technique.
It was found that vitamin D level was not significantly different among patients and controls. The rs10735810, rs1544410, rs7975232, and rs731236 were associated with the onset of arthritis at both allelic and genotypic level (p < 0.01).
Nucleotide change on rs10735810 site leads to change of tryptophan with arginine. The frequencies of haplotype CGAT, CGGA, CGGT, CTAA, CTAT, TGAA, TGAT, TGGA, and TTGA were higher in patients and act as risk factors of RA onset, whereas haplotypes CGAT, CGAT, CGGT, CTGA, TGAT, TGGA, TTAA, and TTGA were associated with OA onset. In conclusion, serum vitamim D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites.
https://www.hindawi.com/journals/bmri/2019/8326246/
In conclusion, serum vit D level may be normal among arthritis patients but polymorphism on VDR gene restricts vit D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites.
https://pubmed.ncbi.nlm.nih.gov/33067526/
. 2020 Oct 16;10(1):17550. doi: 10.1038/s41598-020-74861-9.
Study of vitamin D status and vitamin D receptor polymorphisms in a cohort of Italian patients with juvenile idiopathic arthritis
Francesca Marini 1, Fernanda Falcini 2, Stefano Stagi 3, Sergio Fabbri 1, Simone Ciuffi 1, Donato Rigante 4 5, Marco Matucci Cerinic 6, Maria Luisa Brandi 7
Affiliations Expand
PMID: 33067526
PMCID: PMC7567873
Abstract
Juvenile idiopathic arthritis (JIA) is the most common chronic arthritis of children and adolescents. Autoimmune mechanisms are suspected to have a central role in its development. Vitamin D is an immuno-modulator in a variety of conditions, including autoimmune diseases.
Low levels of vitamin D have commonly been found in JIA patients, but the influence of this hormone insufficiency in JIA pathogenesis is still unclear. Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D. In this study, we analysed clinical characteristics of a cohort of 103 Italian JIA patients.
The distribution of VDR polymorphisms in affected patients versus healthy controls was evaluated, as well as if and how these polymorphic variants associate with different disease presentations (active disease vs non-active disease), different JIA subtypes, serum levels of 25-hydroxy-vitamin D and parathyroid hormone (PTH), and lumbar spine Z-score values (osteopenia vs normal bone mineral density). A great majority of our JIA patients (84.5%) showed a suboptimal vitamin D status, in many cases (84.1%) not solved by vitamin D supplementation.
Vitamin D status resulted to be independent of VDR genotypes. ApaI genotypes showed a highly significant different distribution between JIA patients and unaffected controls, with both the TT genotype and the T allele significantly more frequent in patient group.
Ethics and dissemination:
Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms.
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5907412/
Apa-I polymorphism in VDR gene is related to metabolic syndrome in polycystic ovary syndrome: a cross-sectional study
Abstract
Background
Polycystic ovary syndrome (PCOS) is a common endocrine disorder determined by polygenic traits as well as environmental factors. Lower vitamin D levels have been detected in PCOS women and related to hormone and metabolic disturbances. Vitamin D acts in tissues through the vitamin D receptor (VDR). VDR gene variants have been associated with worse metabolic profile in the general population. We investigated the genotype and haplotype distribution of the Bsm-I (rs1544410), Apa-I (rs7975232), and Taq-I (rs731236) VDR gene polymorphisms in PCOS and non-hirsute women from southern Brazil. We further investigated the associations of these gene variants and their haplotypes with PCOS, vitamin D levels, and metabolic abnormalities, including the metabolic syndrome (MetS).
Methods
A group of 191 women with PCOS (Rotterdam criteria) and 100 non-hirsute controls with regular ovulatory cycles were genotyped for all polymorphisms by real-time PCR, with allelic discrimination assays. MetS and the cutoffs for its isolated components were defined in accordance with the Joint Scientific Statement.
Results
Women with PCOS were younger and had significantly higher BMI and total testosterone levels than controls (p < 0.05). The frequency of MetS in PCOS and controls was 26.5% and 4.8% respectively. The CC genotype of Apa-I entailed higher risk of MetS in PCOS (OR: 2.133; 95% CI 1.020–4.464, p = 0.042), and was associated with higher systolic blood pressure (p = 0.009), total cholesterol (p = 0.040), and LDL-cholesterol (p = 0.038) in both PCOS and control groups (two-way ANOVA). The frequencies of VDR haplotypes were similar in PCOS and control women.
And this is why Liposomal D3/K2 should be trialled.
Kat White
5.0 out of 5 stars Finally! A Vitamin D supplement I can absorb!! Game changer!
Reviewed in the United States on October 27, 2021
Verified Purchase
I’ve been fighting chronically and at times dangerously low vitamin D levels since my late 20s. For several years, I had to be on Rx-only Vit D of 50,000 ius weekly and monitored regularly because it took so long for even THAT to get my level up to normal. (30). My docs were worried about the host of health issues (heart disease, bone loss etc) as someone of my age should have been in the 60s range.
I eventually had to start tanning to maintain a level around 35, at which point my docs weren’t thrilled about but had to settle for as it seemed no matter what, I just couldn’t store or absorb Vit D like most people.
THEN, I listened to a talk from a Cardiologist and he mentioned the importance of taking a D3 supplement with K2 in it. I googled the most absorbable D3/K2 supplement and found this brand. It was super affordable so I thought what the heck? I’ll try it!
After only 3.5 weeks of swallowing one of these tiny little gel capsules every night, I had my well woman’s visit and asked my doc to check my Vit D level because I’m always worried about it. I was FLOORED when she called back to let me know my level was 52!!!
10 years of struggling just to stay over the 30 benchmark always bothered me, and I could see in the eyes and hear the sigh of my docs / dentists who knew it was taking a toll on my health already (osteopenia by age 32) and some depression too….but the long term effects on my heart etc haunted me, as I’m very healthy otherwise.
This product has been a God-send for me. Sooooo thankful to be alleviated of this worry! Thank you SCIENCE!! Thank you Liposomal Vitamin D3 K2 MK7 - 365 Softgels | VIT D3 5000 IU + K2 100 mcg with Organic Coconut oil, thank you AMAZON!!
Kimmy
5.0 out of 5 stars Raised my levels from 34 to 80
Reviewed in the United States on July 16, 2021
Verified Purchase
I'm a believer in this product because of test results. I have my D levels checked about every 18 months and the past two tests didn't budge from the low 30's even though I've been taking D3 supplements and then switched to a combo D3/K2 for the past couple of years. I started taking Upnourish Liposomal about 4 months ago and my results came back this week at 80.
Nadia G 5.0 out of 5 stars Highly recommend
Reviewed in the United States on February 17, 2021 Verified Purchase
I have recently been introduced to liposomal vitamins. I am very deficient in vitamin d and have to take higher doses then normal. I have had these for about 3 weeks and feel a big difference already. I feel my body absorbs these well. There is no flavor which is normal and they are pretty easy to swallow.
Djustblessed 5.0 out of 5 stars The best thing since sliced bread.
Reviewed in the United States on February 20, 2021 Verified Purchase
My body was in sooo much pain. When I walk my joints were cracking, my mood was depressing. I was going weight and I just didn’t feel like myself. I take liposomal vitamin c so I decided to give liposomal vitamin d3 a try. Boy oh boy, so glad I did. I noticed results in about 4-5 days. After 7 days I wasn’t depressed or sad. After 3 weeks, I realized I was happy and back to myself. I have bought 3 extra bottles to give to my family members because they were complaining about some of the things I was complaining about. I have more energy too. I actually feel like doing things again. Highly recommend.
Robert G. 5.0 out of 5 stars Good Product
Reviewed in the United States on May 1, 2021 Verified Purchase
This is a good source for vitamin D at a good price. I was having trouble getting my vitamin D level up to the normal range, despite taking as much as 5000 IU per day. The problem is absorption. Vitamin D taken with lipids (fat) is much more absorbable and this product simply couples a high dose with lipids so that it will be absorbed. I noticed a difference in my mood within days of starting on this product. I'll be checking my vitamin D level again soon to verify that it is really working, but I'm confident that it is. This is a large dose and appropriate for a large person (I am 230 lbs), so check with your physician to make sure it will be right for you.
10 people found this helpful
ABHISHEK S. 5.0 out of 5 stars easy to swallow Reviewed in the United States on April 4, 2021 Verified Purchase
these gel caps are small and easy to swallow. i would have liked them to be vegan but they are coated with bovine gelatin. i measured my d levels two weeks into taking these one a day and my levels are still below normal. now i am taking 35000 units a day after reading about the coimbra protocol to see if my vitiligo lesions improve. i will be measuring my d levels again in a couple months to see how they change with this supplement. the capsules have a slight sweet taste which makes it pleasant on the tongue and easy to swallow without water because they are small and smooth.
6 people found this helpful
brownjackie624 5.0 out of 5 stars Super easy and potent
Reviewed in the United States on March 7, 2021 Verified Purchase
My doctor suggested a D supplement and this one is easy to swallow and remember every day. It’s a fantastic value to have all year long.
7 people found this helpful
amparo sanchez 5.0 out of 5 stars I love it. Reviewed in the United States on January 25, 2021 Verified Purchase
Liposomal vitamin D is excellent for me with organic coconut oil. I love it. I'll buy it again
9 people found this helpful
Anna M. 5.0 out of 5 stars A years supply! Reviewed in the United States on November 11, 2021 Verified Purchase
I like that it is a years supply. They are small and easy to swallow with no taste. I have taken these for about 2 months every single day and since then I have noticed a considerable change in my mood and energy levels. My Doctor said I was vitamin D deficient and recommended I get some. I have taken vitamin D from nature made and multis from ritual but never had any noticeable change from supplements or vitamins before. I'm not sure these would provide mood support or more energy for someone already getting enough, but if you are deficient, these are worth it.
One person found this helpful
cmichelle 5.0 out of 5 stars Good Buy Reviewed in the United States on February 5, 2021
Verified Purchase
The size of these are great! They are small and easy to swallow. I can not attest to their effectiveness with regards to lab results but so far I am pleased with them.